Antibody diversity: A link between switching and hypermutation

نویسنده

  • Michael Lieber
چکیده

Recent work indicates that mutations in a cytidine deaminase homologue ablate both immunoglobulin class switch recombination and somatic hypermutation. These findings now explain cases of autosomal hyper-IgM syndrome and reveal that critical components for key functions of B cells require RNA editing.

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عنوان ژورنال:
  • Current Biology

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2000